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I heard the following phrase:

...get jacked on scag/skag and then get to work.

Source: Saturday Night Live

What do "get jacked" and "scag/skag" mean in this sentence?

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To get jacked on scag is to get high—become intoxicated—on heroin.

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The expression jack up is recent and informal, so there is a lot of variation in usage. In the example you quoted, the up was omitted. It probably comes from the Scottish slang jag, meaning an injection.

jack up - informal Inject oneself with an illegal drug.

scag - heroin

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