The use of a different reference drug requires a detailed scientific justification, as well as additional documents and data.
The word "justification" is marked as both countable and uncountable in dictionaries, and I'm not sure whether a is necessary here.
Maybe it works both ways, with or without "a"? I feel like with "requires" it works both ways, while with "calls for" it feels like "a" is necessary.
The use of a different reference drug calls for a detailed scientific justification, as well as additional documents and data.