4

I'm translating a text where a 4-parameter dose-response log curve is fitted to experimentally obtained data. The text says:

The obtained dose-response curve (S-shaped) should contain points on the upper and lower plateaus and at least 4 points in the linear region and bending regions.

As I understand, there should be data points at the very top and the very bottom of the curve, and 4 data points belonging to the range that includes the "linear region" (where the curve goes at a slant linearly) and the two "bends".

Do they call them "bending regions", "bends" or "inflecting regions", "inflections" or something else?

enter image description here

4

These are the "knees" of the curve.

An exponential curve is self-similar, but it still has a "knee". The "knee of the curve" (of an exponential) is where it visually appears to change from being approximately horizontal to approximately vertical.

Mathematically, an S-curve is very similar to a pair of exponential curves joined at the S-curve's midpoint. Thus, it makes sense to call the transitions between the middle "linear" portion and the tails "knees".

| improve this answer | |
  • Very interesting, and I'm surprised to say I've never come across this definition until now! – Phylyp Mar 20 '17 at 19:51
  • I've heard the term "knee" used very commonly in relation to the current-voltage curves for diodes, which have a similar shape. – LMS Mar 20 '17 at 20:24
3
+50

The curve you've displayed there is the representation of a Sigmoid function or Logistic function. In fact, the picture you've used seems to be very similar to that used for the logistic function on Wikipedia. :-)

The points on that curve are:

  • The inflection point - this is at the very centre of the picture, where the blue line crosses '0.5' (i.e. at the coordinates (0, 0.5) ). This inflection point represents the point where the concave curve on the left becomes a convex curve on the right (concave/convex assuming it's viewed from the top down)
  • The critical point/stationary point - these are the points indicated by the pink arrows. In layman's terms this is where each of the curves turn (or in automotive terms, it is the apex of a corner).
| improve this answer | |

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.