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About toilet talk in English, is there the expression like the following?

Would you like to go upstairs?

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This wikipedia link contains English slang similar to the above, many of which I have never heard. The closest appears to be

Going to the little girls'/little boys' room

which is AmE, or

Going to the office

although I don't believe I have ever heard this. If you mean an expression that states using the bathroom, not "going to _______," but politely, try

Answer nature's call

Going number one (or number two for solid stuff)

Relieve oneself

Taking a leak

Dropping a load

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    The last several look fine to use. I would NOT suggest using going to the office or going to the little boys/girls room. – Ringo Apr 18 '17 at 3:16
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    "Dropping a load" is hardly polite. "Going to the men's [or ladies'] room" would be typical for a business situation. – The Photon Apr 18 '17 at 5:46

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