Do you have examples of uses of "that" "those", etc... in a derogative way.
The question seems kind of broad, but I will briefly talk about it and that.
Imagine two girls, A and B. B is dating a man, C. A thinks C is ugly and not worth dating. Normally, we don't use that to refer to a person. We use the personal pronouns, like him or her. But we can use that to suggest that a person is less than human. I assume this is widely understood as derogatory.
B shows a picture of C to A.
A: I can't believe you're going out with that.
That would be stressed.
Imagine further that C comes over to visit A and B. Upon his arrival, A decides that she dislikes C more because, in her opinion, he's dirty and disgusting. We don't normal use it for people. Instead, we use he or she. But it can be used similarly to that above. Imagine that C shakes hands with A. Later, A might say
Ew. I can't believe it touched me.
It would be stressed.