Does it mean "Open an Excel sheet and work with it"?
"By 2008, Deane, who was at various times an accountant, stay-at-home mom and university employee, had a simple plan to launch a business; it started with tea in the kitchen. "I thought, obviously, what you do is you go home, and if you are British, you have a cup of tea, and you put the computer on in the kitchen and you get excel up," she says."
get {bare infinitive} up
, @haile. The pattern is "get {something} up" and the only "something" called "excel" is a software program called "Excel".