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Does it mean "Open an Excel sheet and work with it"?
"By 2008, Deane, who was at various times an accountant, stay-at-home mom and university employee, had a simple plan to launch a business; it started with tea in the kitchen. "I thought, obviously, what you do is you go home, and if you are British, you have a cup of tea, and you put the computer on in the kitchen and you get excel up," she says."
Get up is a phrasal verb meaning "to awaken." It can take an object like get X up meaning to awaken X from sleep.
This can be figuratively used to mean "to start" or "to prepare for use."
It usually implies that doing this is a process and takes some time.
We can infer two things from this figurative use of get up:
that Deane's computer may be old and slow and takes a while to start Excel,
that Deane likely keeps Excel open all day.
get {bare infinitive} up, @haile. The pattern is "get {something} up" and the only "something" called "excel" is a software program called "Excel". – Tᴚoɯɐuo May 15 '17 at 19:45