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This is my basic sentence :

.... They try to make his life better.
However, Life is not that easy cake which turns to what we want...

My research shows that I can do :

Using ‘however’ to mean ‘in whatever manner’, ‘by whatever means’ or ‘to whatever extent’

Is it really my case here ?

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It isn't your case here. In your sentence "however" means "nevertheless" (Grammar-monster):

When however means nevertheless, it is followed with a comma. When however means to whatever extent, there is no comma after it. For example:

  • I like oats. However, I cannot eat flapjacks. (nevertheless)
  • I like oats. However much I try, I cannot eat flapjacks. (to whatever extent)
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