Can I say "I prefer texting to talking to someone in-situ"?
I feel like I heard someone say that before. But I am not able to find the source.
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In situ is not a common English phrase in casual conversation. It's a more formal term that means "in its original or proper place", although the meaning can vary considerably depending where it's used.
If you want to use it about a person, you may do so ironically to imply that person never leaves a particular location, as if you are a biologist going to visit a rare or delicate species which must not be moved from its local environment.
Since Greg never leaves his mother's basement, and he doesn't answer texts, I went to talk to him in situ.