It is from Crash Course Anatomy & Phisiology. It is at around 1 minute and 30 second to 2 minute. Here it goes:

Because, as unpleasant as a stick in the eye or tack in the foot may be, pain actually is a great example of where everything we have talked about over the last few weeks all come together. As we trace a pain signal through the nervous system, from the first cuss to the Hello Kitty band aid.

Dictionaries say that cuss is the smae as curse, but still cannot understand what it means there.

  • When people step on a tack, or cut themselves, or experience some other sharp sudden pain, they often say %@!*!* That expletive [for example, "dammit!" or "shit!" or "oh fuck!"] is the first cuss (the author may also be playing on the phrase "the first kiss"). – Tᴚoɯɐuo Mar 18 '18 at 13:12

To build on @Tᴚoɯɐuo's comment:

A "cuss" can by anything from a mild "ouch!" to a vulgar profanity. See the definition of cuss (noun), follow the (b) link to the definition of curse (noun), definition #2. The word "cuss" was originally a dialectic pronounciation of the word "curse" that fell into common use.

The speaker was being overly dramatic to create an atmosphere of fun while speaking about a normally dry and boring topic.

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