It is from Crash Course World History. It is at around 5 minute and 8 second. Here is the context:
Human beings, regrettable though it may be, are inherently vicious, and have to be restrained from their viciousness.
Would it mean the same if the host said it this way?
Human beings, though it is regrettable, are inherently vicious, and have to restrained from their vicikusness.
If he could, then why did he use may be?