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If I want to know the connection between A and B. Can I say

"What is the business A with B?"

?

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    No. From the first sentence in your question, that's not the same. (And it needs to be business with A and B to be grammatical.) Why can't you just say, What's the connection between A and B? However, if I go by the title of your question (which is asking something else), then the opposite of It's nobody's business is either it's somebody's business or it's everybody's business, depending on your interpretation. You should edit your question to make it clear exactly what you're asking. – Jason Bassford Jan 11 at 9:11
  • “What does this have to do with me?” – Administrator Feb 9 at 3:04
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What business does A have ...?

Normally the question is asked in a sceptical or even an irate manner.

What business does she have asking my assistant to run a report for her?

The meaning is, "She has some nerve asking my assistant to do work for her."

If you simply want to know how A and B are involved:

What is GM's business with Acme Widgets?

What on earth is Tesla's business with Petco?

The usual, most natural way is to use the possessive: GM's business or Tesla's business

not the periphrastic form with of:

the business of GM with Acme Widgets somewhat unnatural.

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