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Can I say

I left the documents on your desk, take them

Or should I say

I left the documents on your desk, take it

Thanks in advance

2

Of course, you should say:

I left the documents on your desk. Take them.

You need the pronoun them because it refers back to a plural noun which, in this case, is documents (plural nouns represent things that are more than one in number). The pronoun it is used for things that are singular (one in number):

I left the document on your desk. Take it.

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The answer is entirely ambiguous because you haven't specified what the person is being told to take:

I left the documents on your desk. Take them. [The documents.]
I left the documents on your desk. Take it. [The desk.]

The above two sentence pairs are both grammatical barring any context.

However, they are only both correct until more context is provided as to the noun that is being referred to; once the referent is identified, then only one of the sentence pairs will be correct—and the intended meaning will determine the appropriate syntax.

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