Does "how come" replace "how can you" in these phrases:

"How come you find the love of your life and walk away?"

"How come you win the lottery and gamble all the money away?"


Sort of. Usually, 'how come' is considered to be a synonym for 'why', but 'why' does not fit very well with the rest of the sentence without quite a bit of writing, so 'how can you' is a reasonable alternative. Or you could say something like:

Why is it that you find the love of your life and walk away?

'How come' and 'how comes' have a long heritage (Edmund Spenser, 1611), but are considered informal and colloquial. It is probably a shortened version of something like "how did it come about that".

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