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Does the following sentence make sense? I mean the last part. Is it correct to use the loss of something to someone as an expression?

The result of the medical test caused a loss of morale to him.

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No, morale isn't something that's transitive—you don't give it to (or take it from) somebody, even though you might cause them to gain or lose it. Morale is something that you have or don't have, it's not transferable.

Your sentence could be rephrased like this:

The results of the medical test caused a loss of morale in him.

(Note that you normally get test results, plural.)

But although that's the right preposition, it's still a bit awkward.


More natural would be one of these phrases:

The results of the medical test caused him to lose morale.
The results of the medical test decreased his morale.

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