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Pakistan said that with the support of China, it will take up India's unilateral actions in Kashmir with the U.N. Security Council and may approach the U.N. Human Rights Commission over what it says is the "genocide" of the Kashmiri people.

What do these its refer to and what does take up mean in this context?

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The antecedent of "it", here is "Pakistan". The text says that Pakistan will take up the matter with the Security Council.

"Take up" is a phrasal verb with many meanings, and this is closest to sense 5 inn the linked def. To "take up a matter with someone" is to raise or discuss that matter with that person, or if it is a group or body, to raise it before the body, or put it on their agenda.

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