According to http://amj.amegroups.com/article/view/4743/html
In the sentence, "This study was designed to imagine the impact of the antioxidant metallothoinein (MT) on 'the' lipopolyssacharide (LPS)-induced cardiac contractile and intracellular Ca2+ dysfunction." the study is referring to precisely the impact of MT on specifically the LPS induced ... dysfunction.
The author of the linked article says, using the zero-article instead of the definite article before 'lipopolysaccharide', the meaning of the sentence becomes that this paper will be looking at how LPS-induced dysfunction will impact MT. So cant use the zero article.
Would you explain me why the definite article is required in the sentence?