According to http://amj.amegroups.com/article/view/4743/html

In the sentence, "This study was designed to imagine the impact of the antioxidant metallothoinein (MT) on 'the' lipopolyssacharide (LPS)-induced cardiac contractile and intracellular Ca2+ dysfunction." the study is referring to precisely the impact of MT on specifically the LPS induced ... dysfunction.

The author of the linked article says, using the zero-article instead of the definite article before 'lipopolysaccharide', the meaning of the sentence becomes that this paper will be looking at how LPS-induced dysfunction will impact MT. So cant use the zero article.

Would you explain me why the definite article is required in the sentence?


The author is not correct. Word order is what defines which thing is impacting which, and it's clear from the quoted sentence that the study is how MT impacts LPS-induced dysfunction.

The definite article is not required here.

It may not even be preferable here, because the study is presumably on all LPS-induced dysfunction, not a specific instance of LPS-induced dysfunction. Compare a simpler, but similar sentence like: "I am studying the impact of cholesterol on heart disease."

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