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I am asking about the sentence this guy (James Wilson, House's best friend) says at 7:00 in this video. The transcription is:

Okay, maybe. But he's our friend and this is his one chance to not be miserable.

I am curious about the ''one chance''. Does one chance work as only chance? Or should I wrote his one-chance?

Still, the biggest question is about the to not be. As far as I know, it is not to. For instance, tend not to, try not to, etc. or also in reported speech: they told us not to. Is it wrong what he says then, or is this situation different from the ones I have cited?

PS: The video corresponds to Chapter 16, Season 5, The Softer Side, as you can see in its description.

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You mean "he's our friend", not "his our friend".

His one chance does indeed mean his only chance.

Both not to be and to not be are possible there. But a choice not to be miserable is a bit vague: we know what the choice is not, but what is it? A choice to not be miserable is much stronger, even if in the end they mean the same thing.

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    There used to be a prejudice against so-called split infinitives - a rule that was made up by grammarians in the 19th century - so you may well have been taught only the not to be form. But most grammarians and style-guides now accept them, though they oft6en advise against them except rfor a particular effect, as here.
    – Colin Fine
    Dec 7 '20 at 20:46

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