You can't remove the word "for". It is part of a "for-to" structure, making the infinitive clause "for the change to be sructural".
This came up in a question yesterday:
Stack Exchange ELL "what does 'for' mean"
That infinitive clause "for the change to be structural" is connected by the verb "is" to "the best way to...".
The word "for" is a marker of the subject of the infinitive clause "the change", and "to" is a marker of the verb "be".
Stack Exchange ELU
To is part of the for-to, or "Infinitive" Complementizer; for marks the Subject, to marks the VP.