What decides where the definite article(s) goes in “A of B”?

Question

Let's take the following for example: “trajectories of hand movement.” Is the only factor that decides which option below is correct whether "trajectories" or "hand movement" has been mentioned beforehand? Is Option 4 always incorrect?

1. A of B: Trajectories of hand movement are similar.
2. the A of B: The trajectories of hand movement are similar.
3. A of the B: Trajectories of the hand movement are similar.
4. the A of the B: The trajectories of the hand movement are similar.