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  1. Which actors do you admire most?
  2. What actors do you admire most?

Which of the two sentences sounds more natural to native speakers?

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Either one can be used.

A few websites I checked (like this one) recommended using which when there are a limited number of choices, and what when there are a seemingly unlimited number of choices.

So, it might be best to say:

Which actor do you admire most – Brad Pitt or George Clooney?

but:

What actors do you admire most?

if you want the person to be able to choose from any actor in all of cinematographic history.

But as for which sounds more natural, I'd need more context to say for sure.

As a footnote, here is a related ELU question.

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