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After reading this discussion: is-there-a-correct-gender-neutral-singular-pronoun-his-vs-her-vs-their, I was wondering if I could use one and singular they together in a sentence.

A sentence for an example:

Quite frankly, one needs to get their head screwed on right.

Is that sentence above acceptable grammatically? I also wonder whether I need the pular form of head i.e. heads after their.

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There's a dissonance between one, which has a formal feeling, and head screwed on right, which is very colloquial.
Apart from that, I think it's better to stick with they:

They need to get their heads screwed on right.

(note plural heads),

or with one:

One needs to have one's arguments ready.

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