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A: Don't you think a bit of distraction might be good for you?
B: I don't know.
A: Well, if you want to do something sometime, just let me know.
B: ...You have something/anything in mind?
A: No, I just thought you might want to get out a little.
I know the difference between 'something' and 'anything' but would one of them for some reason seem more natural than the other in this context?
To me, both of these sound natural, and it seems to me like something that someone would actually say. The only thing I would add is ‘do’ at the start:
Do you have anything in mind? Do you have something in mind?
Another thing: Saying ‘something might’ imply you are looking for something more specific.
