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We can say 'A brother of mine is a doctor.' The more common way of saying is 'One of my brothers is a doctor.'
But in a case where a listener knows my brother or I have only one brother.
Should we write 'the brother of me is a doctor.' Using 'mine' is wrong here as Mine would represent 'my brothers'(more than one brothers) ?
I know there are other better ways to say it but I want to know that this one is grammatically correct or not.
You seem to be thinking that "mine" is only used with a plural. That is incorrect.
In general, we rarely say "[whatever] of mine". We generally say "my [whatever]". But "of mine" is grammatically valid.
One of my brothers is a doctor. <- valid and the common way we would say this
A brother of mine is a doctor. <- valid but fairly uncommon
My brother is a doctor. <- valid and common
The brother of mine is a doctor. <- grammatically valid but I've never heard someone say this
Okay, someone MIGHT use that phrasing if he was contrasting his brother with someone else's brother. Like:
"Jack and I both have brothers who went to Podunk University. The brother of Jack is now an engineer and the brother of mine is now a doctor." Less weird sounding but still unlikely. We'd be more likely to say, "Jack's brother ... but my brother ..."
If the listener knows your brother, or that you only have one, what's wrong with My brother is a doctor?
You would only use a brother of mine if the listener doesn't know him and his identity is unimportant - you are just saying it to explain why you know something about the medical profession.
No, never is brother of me right. Very simple.
of mine, of yours, of his/hers, of ours, of yours, of theirs.
Those are the correct possessive pronouns after of.
That's it.
