Are there any singular words that mean that something feels off? Not about a person, but about something in general. E.g.
The abandoned building made me feel _____.
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One might say "uneasy":
causing or feeling anxiety; troubled or uncomfortable
So this word fits your sentence, your intuition/gut feeling tells you that something is off about the abandoned building, which made you feel uneasy.
Aside from variations of "made me feel X", there are also alternatives like
There is some variation of how extreme the "feeling off" is, and some can also be used in other situations (like normal excitement).