Can you explain more? I do not know when we can use them in the sentence. Can we use them instead of each other?
They have a beautiful home.
They have a beautiful house.
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A home is a metaphysical concept of where you live. My home is in an apartment building, on the second floor. I can welcome people into my home.
A house is generally used to mean a single-family dwelling, or at least a building used exclusively for a small number of people, perhaps to include a duplex house.
In your case, "They have a beautiful home," probably more implies that they decorate well and keep it up nicely. A "beautiful house" would probably mean the building itself is fancy, without saying anything about the decorations or people or their taste.
Your house is the physical structure made of stone/wood/brick in which you live
Your home is the place where you belong. It can be a house, an apartment, or even a society. It is more personal than a house
They have a beautiful house
could mean that the house looks nice, perhaps because it's expensive or is well decorated
They have a beautiful home
could mean that it feels nice at their place, maybe because the people living there are a nice family or it's a peaceful neighborhood
The term home typically refers to a more intimate description of a dwelling. A quote about this is "It takes hands to build a house, but only hearts can build a home" (I cannot find an author for that quote). Home is some place special to you; a house is what the neighbors live in. In your example question, either use is acceptable in my opinion.
From Google Search:
A building for human habitation, especially one that is lived in by a family or small group of people.
The place where one lives permanently, especially as a member of a family or household.
A house is a singluar building - it can hold many or one (Or none if unowned or unoccupied) people. A home can be a house, but it can also refer to any place that a person lives in a permanent manner (An apartment/flat, a duplex, a trailer, or even more abstractly a "home" city or a "home" country).
Relationally, a house can be a home, but a home is not always a house.
Home: Generally used as a term to describe a HOUSE with a family or people living in it:
The family sits around the fire in their home.
It also generally describes the contents for example in this sentence a home would not be cozy without its contents or people, yet we would still say :
The home was very cozy.
House: Generally used to describe the building itself:
The house was up for sale on the market.
Thanks, hope this helps!