Something went wrong with you. Something went wrong to you. Which is the correct answer? What is the difference between them?
is indicating movement, direction or intention toward you.
I am sending the package to you.
I am speaking to you.
Happy Birthday to you!
Similar to your example, you could say:
Something happened to you.
which indicates an action (ex. What happened was that I hit my finger with a hammer).
As for your example:
Something is/went wrong with you.
is better, because it is more about describing your current state or condition, not movement (generally the case using to be).