Can I use 'do not take leave' here?
Mithilesh and me do not take leave this month.
Any help is appreciated.
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Assuming the context is future tense...
First, correct 'Mithilesh and me' to 'Mithilesh and I'. (tip: Try the sentence without including Mithilesh, would you use Me or I?)
The first example is more informal usage. The second adds the article ('a') and the type of leave, which would be a more rigorous or complete way to say this. The third is an alternative way of using the term leave in this context.
However, if you are simply trying to convey that you and Mithilesh will be on duty for the entire month, you may wish to state that, as there are other reasons that you may be absent during the month.