This is a line from a movie called Being John Malkovic
Carrot juice, and lots of it.
I need to know why the comma is used in the above sentence. Is "lots" the subject in it, and thus it is an independent clause and so a comma is there?
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The comma is there to help you parse the sentence more easily. In general, it puts a lot of strain on people to have to backtrack sentences if you get stuck somewhere; this is exactly why we use punctuation.
Consider the sentence without the comma. You will start reading from left to right:
Carrot juice ....
Good. That sounds like a subject.
Carrot juice and lots of ...
OK. Apparently, the subject consists of two things: carrot juice, and lots of something else - perhaps quinoa or açai berries? Those are healthy! I wonder what the verb will be...
Wait. We're already at the end of the sentence? Where's the verb? What's the 'it' about? If you started on the wrong foot with this sentence, you will need to backtrack to see where you went wrong.
Let's take another look, now with the comma.
Now we have some noun without anything to go with it - we guess it's just an utterance like 'Jummie, pie!'.
and lots of it.
Yep. Definitely. Basically, the comma helps you see that the 'and' connects two utterances - without a comma, we'd think that the subject consists of multiple parts!
For cases where a comma can make the meaning of a sentence more ambiguous, I recommend reading on the Oxford Comma.