My doubt is about using the word "cranial" here. Does this make sense?

This is great. I am glad I was able to activate something cranial in you.

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    Cranial: connected with the cranium cranial nerves/injuries oxfordlearnersdictionaries.com/definition/english/cranial - I think you mean cerebral: (formal) relating to the mind rather than the feelings: oxfordlearnersdictionaries.com/definition/english/… – user5267 Jun 11 '16 at 16:42
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    Proof-reading is off-topic; and what research have you done? Please refer to the Help page. – TrevorD Jun 11 '16 at 16:43
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    @TrevorD This isn't a request for proofreading. It's a request about word usage. Cranium means skull and is used figuratively to refer to the brain, as in Use your cranium. The adjective is a poor fit for brain activity as Josh61 points out. – deadrat Jun 11 '16 at 16:57
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    You don’t mean “your doubt” — you mean “your question”! – tchrist Jun 11 '16 at 18:11
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    It is not incorrect. It does represent a jocular manner of expression, however, and cannot be considered "formal". – Hot Licks Jun 11 '16 at 19:31

activate something cranial in you is likely to be taken for mild or jocular sarcasm.

It's a more erudite way of saying, "I'm glad I was able to get that idea into your thick skull."

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