There was a question in the comments: "For which country are you asking?" Each country is different. Here's an example from the USA. The formats might vary, so this isn't the absolute rule.
28 Apple Street, apt. 5
Los Angeles, California 90210
In other words,
City, State Zipcode
Where should insert a line ...
The first sentence could be phrased without a comma as
This is my sister Jane.
which is now phrased in a way similar to the second sentence. Here, it is the first comma which should go.
The distinguished scientist Mr. Stephen, of AKL University, will be addressing the crowd tomorrow.
It is precisely because Mr Stephen's university is non-essential, ...