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Mixed conditionals that combine simple past in the conditional and conditional perfect in the result usually refer to a present condition and a past result: If she didn't like arguments, she would have avoided the situation. (However, she does like arguments and, as a result, she didn't avoid the situation.) I can only understand the sentence proposed if ...


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I don't see anything wrong with the statement you have written, in either of the two contexts you have described. However, I don't necessarily see anything wrong the modifications you have proposed either. In context A (the person referred to as you in the statement has taken and completed the nuclear physics course), you might prefer "If you hadn't have ...


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EDIT: You should use the first one, i.e. "The following three major challenges have to be met if a family business is to flourish for 100 years and more." Since a family business to flourish for 100 years and more is not impossible, you should be using Future Real Conditional explained here: Future Conditional Forms | ENGLISH PAGE Future Real ...


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