Is there any difference in meaning between blame and accuse or are they interchangeable? I looked both of them up in the dictionaries and couldn't figure out if there's any difference between them. Dictionary Definitions Accuse → If you accuse someone of doing something wrong or dishonest, you say or tell them that you believe that they did it. Blame → If you blame a person or thing for something bad, you believe or say that they are responsible for it or that they caused it.