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Suppose I have a doctor’s appointment and I want to give it to my sister. I want to ask my doctor if it is OK. Is using “instead of me” correct?

I have an appointment on Friday. Can my sister come instead of me?

Are there any better alternatives to that?

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It's absolutely fine.

I should have let her come instead of me. I knew she wanted to come.

You can go instead of me, if you want.

You could also use in place of somebody or in somebody's place:

I'm going to lead the meeting in place of Janet because she went home sick.

He was unable to go to the ceremony, but he sent his son in his place.

When her manager fell ill, she was asked to attend the sales conference in his place.

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