He emptied his pockets of loose change.
My native language which is not English wants to rewrite the sentence as this:
He got rid of loose change from his pockets. Or, He emptied his pockets (from loose change).
Does the 'of' mean 'from'?
The pattern is like 'deprive A of B', 'rob A of B' and it is a little weird that why the direct object B comes later using 'of'
He emptied his pockets of loose change.
means the same thing as
He removed all loose change from his pockets.
Your alternative:
He emptied his pockets from loose change
Is not natural in standard English, at least not in the US or UK. More generally,
He emptied X of Y
means that he took all the Y out of X. It may or may not imply that Y was the only thing in X. It does imply that at least some Y was present.
